Increases in ultraviolet radiation at the Earth's surface due to the depletion of the
stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects …

The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …

Mutational processes constantly shape the somatic genome, leading to immunity, aging,
cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into …

DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and
transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes …

Expressed genes are scanned by translocating RNA polymerases, which sensitively detect
DNA damage and initiate transcription-coupled repair (TCR), a subpathway of nucleotide …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

DNA damage is implicated in cancer and aging, and several DNA repair mechanisms exist
that safeguard the genome from these deleterious consequences. Nucleotide excision …

▪ Abstract The biological impact of any DNA damaging agent is a combined function of the
chemical nature of the induced lesions and the efficiency and accuracy of their repair …

The SNF2 family of proteins includes representatives from a variety of species with roles In
cellular processes such as transcrlptional regulation (eg M0T1, SNF2 and BRM) …

A mammalian nucleotide excision repair (NER) factor, the XPC–HR23B complex, can
specifically bind to certain DNA lesions and initiate the cell-free repair reaction. Here we …