Functional properties and genomics of glucose transporters

FQ Zhao, AF Keating - Current genomics, 2007 - ingentaconnect.com
Glucose is the major energy source for mammalian cells as well as an important substrate
for protein and lipid synthesis. Mammalian cells take up glucose from extracellular fluid into …

Insulin signalling mechanisms for triacylglycerol storage

MP Czech, M Tencerova, DJ Pedersen, M Aouadi - Diabetologia, 2013 - Springer
Insulin signalling is uniquely required for storing energy as fat in humans. While de novo
synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary …

Mulberry leaves ameliorate diabetes via regulating metabolic profiling and AGEs/RAGE and p38 MAPK/NF-κB pathway

J Li, T Ji, S Su, Y Zhu, X Chen, E Shang, S Guo… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Mulberry leaves have been used as traditional
hypoglycemic medicine-food plant for thousand years in China. According to traditional …

Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome

E Fuentes, F Fuentes, G Vilahur… - Mediators of …, 2013 - Wiley Online Library
The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence
of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is …

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

S Al‐Lahham, H Roelofsen, F Rezaee… - European journal of …, 2012 - Wiley Online Library
Eur J Clin Invest 2012; 42 (4): 357–364 Abstract Background Adipose tissue is a primary site
of obesity‐induced inflammation, which is emerging as an important contributor to obesity …

Estrogen and glycemic homeostasis: the fundamental role of nuclear estrogen receptors ESR1/ESR2 in glucose transporter GLUT4 regulation

KCR Gregorio, CP Laurindo, UF Machado - Cells, 2021 - mdpi.com
Impaired circulating estrogen levels have been related to impaired glycemic homeostasis
and diabetes mellitus (DM), both in females and males. However, for the last twenty years …

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice

J Xu, SR Kulkarni, AC Donepudi, VR More, AL Slitt - Diabetes, 2012 - diabetesjournals.org
The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in
the pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep …

An exopolysaccharide from Lactobacillus plantarum H31 in pickled cabbage inhibits pancreas α-amylase and regulating metabolic markers in HepG2 cells by AMPK …

Z Huang, F Lin, X Zhu, C Zhang, M Jiang… - International Journal of …, 2020 - Elsevier
In this study, we investigated the structural characterization and antidiabetic effects of
Lactobacillus H31 exopolysaccharide (EPS) H31-2 from pickled cabbage. The BLAST result …

Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes

C Brännmark, E Nyman, S Fagerholm… - Journal of Biological …, 2013 - jbc.org
Type 2 diabetes originates in an expanding adipose tissue that for unknown reasons
becomes insulin resistant. Insulin resistance reflects impairments in insulin signaling, but …

Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology

E Karnieli, M Armoni - American Journal of Physiology …, 2008 - journals.physiology.org
The insulin-responsive glucose transporter 4 (GLUT4) plays a key role in glucose uptake
and metabolism in insulin target tissues. Being a rate-limiting step in glucose metabolism …