Protein homeostasis mechanisms are fundamentally important to match cellular needs and
to counteract stress conditions. A fundamental challenge is to understand how defective …

The controlled entry and expulsion of small molecules across the bacterial cytoplasmic
membrane is essential for efficient cell growth and cellular homeostasis. While much is …

Rhomboid proteases hydrolyze substrate helices within the lipid bilayer to release soluble
domains from the membrane. Here, we investigate the mechanism of activity regulation for …

Bacillus licheniformis α-amylase is a thermostable enzyme used in industrial starch
hydrolysis. However, difficulties in the genetic manipulation of B. licheniformis hamper …

We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11
Klebsiella pneumoniae carbapenemase 2–producing K. pneumoniae. Plasmid …

Due to the presence of a transmembrane domain, the subcellular mobility plan of membrane-
bound or membrane-tethered transcription factors (MB-TFs) differs from that of their cytosolic …

ABSTRACT OXA-232 is one of the most common OXA-48-like carbapenemase derivatives
and is widely disseminated in nosocomial settings across countries. The bla OXA-232 gene …

Protein aggregates are a common feature of diseased and aged cells. Membrane proteins
comprise a quarter of the proteome, and yet, it is not well understood how aggregation of …

Protein degradation is fundamentally important to ensure cell homeostasis. In the
endoplasmic reticulum (ER), the ER-associated degradation (ERAD) pathway targets …

Rhomboid pseudoproteases are catalytically inactive members of the rhomboid superfamily.
The founding members, rhomboids, were first identified in Drosophila as serine …