Breast cancer is a global cause for concern owing to its high incidence around the world.
The alarming increase in breast cancer cases emphasizes the management of disease at …

PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with
germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 …

Abstract Purpose of Review Despite a steady improvement in breast cancer survival rates
over the past several decades, mortality disparities remain among Black women, who have …

PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …

PURPOSE To determine the sensitivity and specificity of genetic testing criteria for the
detection of germline pathogenic variants in women with breast cancer. MATERIALS AND …

PURPOSE To determine the contribution of germline pathogenic variants (PVs) in hereditary
cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS …

Background: Several available data suggest the association between specific molecular
subtypes and BRCA1/2 mutational status. Previous investigations showed the association …

The majority of breast cancers are diagnosed at an early stage and are hormone receptor
(HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative. Significant …

Recent advances in the detection of germline pathogenic variants (PVs) in BRCA1/2 genes
have allowed a deeper understanding of the BRCA-related cancer risk. Several studies …

Here, we present the case of a 47-year-old woman diagnosed with luminal B breast cancer
subtype and provide an in-depth analysis of her gene mutations, chromosomal alterations …