Anxiety is experienced in response to threats that are distal or uncertain, involving changes
in one's subjective state, autonomic responses, and behavior. Defensive and physiologic …

Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Generalization of conditioned fear is adaptive in some situations but maladaptive when fear
excessively generalizes to innocuous stimuli with incidental resemblance to a genuine …

Anxiety disorders are the most common mental disorders and are often chronic and
disabling. Although exposure-based treatments are effective, a substantial number of …

Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli
and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the …

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

The generalization of fear memories is an adaptive neurobiological process that promotes
survival in complex and dynamic environments. When confronted with a potential threat, an …

The hippocampus and its extended network contribute to encoding and recall of episodic
experiences. Drawing from recent anatomical, physiological, and behavioral studies, we …

The dentate gyrus–CA3 circuit of the hippocampus is continuously modified by the
integration of adult-born dentate granule cells (abDGCs). All abDGCs undergo a prolonged …

Adult hippocampal neurogenesis (AHN) represents a remarkable form of neuroplasticity that
has increasingly been linked to the stress response in recent years. However, the …