Hyperglycemia during stress is a common occurrence seen in patients admitted to the
hospital. It is defined as a blood glucose level above 180mg/dl in patients without pre …

Objective: To evaluate the literature and identify important aspects of insulin therapy that
facilitate safe and effective infusion therapy for a defined glycemic end point. Methods:

Introduction Hyperglycemia, hypoglycemia and increased glucose variability are
independently associated with increased risk of death in critically ill adults. The relationship …

Intensive insulin therapy (IIT) and tight glycaemic control (TGC), particularly in intensive care
unit (ICU), are the subjects of increasing and controversial debate in recent years. Model …

Background The changes in metabolic pathways and metabolites due to critical illness result
in a highly complex and dynamic metabolic state, making safe, effective management of …

Objective To systematically review the medical literature on the association between
glucose variability measures and mortality in critically ill patients. Methods Studies …

Hyperglycemia is associated with poor clinical outcomes in critically ill patients. Initial clinical
trials of intensive insulin therapy targeting blood glucose levels of 80 to 110 mg/dL showed …

Introduction Closed-loop (CL) systems modulate insulin delivery according to glucose levels
without nurse input. In a prospective randomized controlled trial, we evaluated the feasibility …

Accurate glycemic control (AGC) is difficult due to excessive hypoglycemia risk. Stochastic
TARgeted (STAR) glycemic control forecasts changes in insulin sensitivity to calculate a …

Tight glycemic control (TGC) has emerged as a major research focus in critical care due to
its potential to simultaneously reduce both mortality and costs. However, repeating initial …