Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

Alzheimer's disease (AD) is the most common form of dementia, affecting more than 50
million people worldwide with an estimated increase to 139 million people by 2050. The …

Background Neuroinflammation is one of the most important processes in secondary injury
after traumatic brain injury (TBI). Triggering receptor expressed on myeloid cells 2 (TREM2) …

Arterial occlusion-induced ischemic stroke (IS) is a highly frequent stroke subtype. Nuclear
factor erythroid 2-related factor 2 (NRF2) is a transcription factor that modulates antioxidant …

Postoperative cognitive dysfunction (POCD) is a common postoperative complication
involving the central nervous system, but the underlying mechanism is not well understood …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane receptor
protein predominantly expressed in microglia within the central nervous system (CNS) …

Increasing life expectancy has led to an aging population, which has consequently
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …

The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that
affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell …

Inflammatory responses and neuronal ferroptosis, which are associated with abnormal
accumulation of reactive oxygen species (ROS), exert crucial damaging effects on the brain …

Ischemic stroke is the second leading cause of death globally. Calycosin is a typical
phytoestrogen that protects against cerebral ischemia/reperfusion (I/R) injury. However, the …