The pig as a model for immunology research

R Pabst - Cell and tissue research, 2020 - Springer
The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

The pig: a model for human infectious diseases

F Meurens, A Summerfield, H Nauwynck, L Saif… - Trends in …, 2012 - cell.com
An animal model to study human infectious diseases should accurately reproduce the
various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to …

Bioprinting decellularized breast tissue for the development of three-dimensional breast cancer models

B Blanco-Fernandez, S Rey-Vinolas… - … applied materials & …, 2022 - ACS Publications
The tumor extracellular matrix (ECM) plays a vital role in tumor progression and drug
resistance. Previous studies have shown that breast tissue-derived matrices could be an …

The porcine innate immune system: an update

KH Mair, C Sedlak, T Käser, A Pasternak… - Developmental & …, 2014 - Elsevier
Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

Lactation-related microRNA expression profiles of porcine breast milk exosomes

Y Gu, M Li, T Wang, Y Liang, Z Zhong, X Wang, Q Zhou… - 2012 - journals.plos.org
Breast milk is the primary source of nutrition for newborns, and is rich in immunological
components. MicroRNAs (miRNAs) are present in various body fluids and are selectively …

Structural and functional annotation of the porcine immunome

HD Dawson, JE Loveland, G Pascal, JGR Gilbert… - BMC genomics, 2013 - Springer
Background The domestic pig is known as an excellent model for human immunology and
the two species share many pathogens. Susceptibility to infectious disease is one of the …

[HTML][HTML] Swine as biomedical animal model for T-cell research—Success and potential for transmittable and non-transmittable human diseases

T Käser - Molecular immunology, 2021 - Elsevier
Swine is biologically one of the most relevant large animal models for biomedical research.
With its use as food animal that can be exploited as a free cell and tissue source for research …

Genome editing in large animals: current status and future prospects

J Zhao, L Lai, W Ji, Q Zhou - National Science Review, 2019 - academic.oup.com
Large animals (non-human primates, livestock and dogs) are playing important roles in
biomedical research, and large livestock animals serve as important sources of meat and …

The toll-like receptor family protein RP105/MD1 complex is involved in the immunoregulatory effect of exopolysaccharides from Lactobacillus plantarum N14

Y Murofushi, J Villena, K Morie, P Kanmani… - Molecular …, 2015 - Elsevier
Abstract The radioprotective 105 (RP105)/MD1 complex is a member of the Toll-like receptor
(TLR) family. It was reported that RP105/MD1 cooperates with the lipopolysaccharide (LPS) …

Human microbiota-associated swine: current progress and future opportunities

M Wang, SM Donovan - ILAR journal, 2015 - academic.oup.com
Gnotobiotic (GN) rodent models have provided insight into the contributions of the gut
microbiota to host health and preventing disease. However, rodent models are limited by …