Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to
address the donor shortage as well as immunologic rejection attributed to cells in …
address the donor shortage as well as immunologic rejection attributed to cells in …
Biological roles of glycans
A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
Evaluation of human and non‐human primate antibody binding to pig cells lacking GGTA 1/CMAH/β4Gal NT 2 genes
JL Estrada, G Martens, P Li, A Adams… - …, 2015 - Wiley Online Library
Background Simultaneous inactivation of pig GGTA 1 and CMAH genes eliminates
carbohydrate xenoantigens recognized by human antibodies. The β4Gal NT 2 …
carbohydrate xenoantigens recognized by human antibodies. The β4Gal NT 2 …
Xenotransplantation: current status in preclinical research
T Lu, B Yang, R Wang, C Qin - Frontiers in immunology, 2020 - frontiersin.org
The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …
Humoral reactivity of renal transplant-waitlisted patients to cells from GGTA1/CMAH/B4GalNT2, and SLA class I knockout pigs
Background Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated
antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells …
antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells …
Transplanting organs from pigs to humans
M Sykes, DH Sachs - Science immunology, 2019 - science.org
The success of organ transplantation is limited by the complications of immunosuppression,
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …
by chronic rejection, and by the insufficient organ supply, and thousands of patients die …
The role of genetically engineered pigs in xenotransplantation research
DKC Cooper, B Ekser, J Ramsoondar… - The Journal of …, 2016 - Wiley Online Library
There is a critical shortage in the number of deceased human organs that become available
for the purposes of clinical transplantation. This problem might be resolved by the …
for the purposes of clinical transplantation. This problem might be resolved by the …
Current status of xenotransplantation research and the strategies for preventing xenograft rejection
Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …
Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid
One of the most consistent epidemiological associations between diet and human disease
risk is the impact of red meat consumption (beef, pork, and lamb, particularly in processed …
risk is the impact of red meat consumption (beef, pork, and lamb, particularly in processed …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …