Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them

N Sharma, S Bhatia, V Chunduri, S Kaur… - Frontiers in …, 2020 - frontiersin.org
Wheat is a major cereal crop providing energy and nutrients to the billions of people around
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …

Cereals for develo** gluten-free products and analytical tools for gluten detection

CM Rosell, F Barro, C Sousa, MC Mena - Journal of cereal science, 2014 - Elsevier
Recently, gluten free foods have attracted much research interest motivated by the
increasing market. Despite the motivation for develo** gluten-free foods it is necessary to …

Low‐gluten, nontransgenic wheat engineered with CRISPR/Cas9

S Sánchez‐León, J Gil‐Humanes… - Plant biotechnology …, 2018 - Wiley Online Library
Coeliac disease is an autoimmune disorder triggered in genetically predisposed individuals
by the ingestion of gluten proteins from wheat, barley and rye. The α‐gliadin gene family of …

CRISPR/Cas9 gene editing of gluten in wheat to reduce gluten content and exposure—Reviewing methods to screen for coeliac safety

A Jouanin, LJWJ Gilissen, JG Schaart, FJ Leigh… - Frontiers in …, 2020 - frontiersin.org
Ingestion of gluten proteins (gliadins and glutenins) from wheat, barley and rye can cause
coeliac disease (CD) in genetically predisposed individuals. The only remedy is a strict and …

Wheat seed storage proteins: Advances in molecular genetics, diversity and breeding applications

A Rasheed, X **a, Y Yan, R Appels, T Mahmood… - Journal of Cereal …, 2014 - Elsevier
Wheat seed storage proteins, especially glutenins and gliadins, have unique functional
properties giving rise to a wide array of food products for human consumption. The wheat …

CRISPR/Cas9-mediated multiplex gene editing of gamma and omega gliadins: paving the way for gliadin-free wheat

S Sánchez-León, M Marín-Sanz… - Journal of …, 2024 - academic.oup.com
Wheat is a staple cereal in the human diet. Despite its significance, an increasing
percentage of the population suffers adverse reactions to wheat, which are triggered by …

An elite γ‐gliadin allele improves end‐use quality in wheat

D Liu, H Yang, Z Zhang, Q Chen, W Guo… - New …, 2023 - Wiley Online Library
Gluten is composed of glutenins and gliadins and determines the viscoelastic properties of
dough and end‐use quality in wheat (Triticum aestivum L.). Gliadins are important for wheat …

[HTML][HTML] Improving wheat to remove coeliac epitopes but retain functionality

PR Shewry, AS Tatham - Journal of Cereal Science, 2016 - Elsevier
Coeliac disease is an intolerance triggered by the ingestion of wheat gluten proteins. It is of
increasing concern to consumers and health professionals as its incidence appears to be …

Outlook for coeliac disease patients: towards bread wheat with hypoimmunogenic gluten by gene editing of α-and γ-gliadin gene families

A Jouanin, JG Schaart, LA Boyd, J Cockram, FJ Leigh… - BMC plant biology, 2019 - Springer
Background Wheat grains contain gluten proteins, which harbour immunogenic epitopes
that trigger Coeliac disease in 1–2% of the human population. Wheat varieties or accessions …

Genomic and functional genomics analyses of gluten proteins and prospect for simultaneous improvement of end-use and health-related traits in wheat

D Wang, F Li, S Cao, K Zhang - Theoretical and Applied Genetics, 2020 - Springer
Key message Recent genomic and functional genomics analyses have substantially
improved the understanding on gluten proteins, which are important determinants of wheat …