Recent insights into the etiopathogenesis of diabetic retinopathy and its management

A Biswas, AD Choudhury, S Agrawal… - Journal of Ocular …, 2024 - liebertpub.com
Purpose: Diabetic retinopathy (DR) is a microvascular retinal disease associated with
chronic diabetes mellitus, characterized by the damage of blood vessels in the eye. It is …

Diabetic retinopathy: new treatment approaches targeting redox and immune mechanisms

Q Tang, F Buonfiglio, EW Böhm, L Zhang, N Pfeiffer… - Antioxidants, 2024 - mdpi.com
Diabetic retinopathy (DR) represents a severe complication of diabetes mellitus,
characterized by irreversible visual impairment resulting from microvascular abnormalities …

Oxidative stress, inflammatory, angiogenic, and apoptotic molecules in proliferative diabetic retinopathy and diabetic macular edema patients

I Andrés-Blasco, A Gallego-Martínez… - International journal of …, 2023 - mdpi.com
The aim of this study is to evaluate molecules involved in oxidative stress (OS),
inflammation, angiogenesis, and apoptosis, and discern which of these are more likely to be …

Optical coherence tomography in the management of diabetic macular oedema

SKH Szeto, TYY Lai, S Vujosevic, JK Sun… - Progress in retinal and …, 2024 - Elsevier
Diabetic macular oedema (DMO) is the major cause of visual impairment in people with
diabetes. Optical coherence tomography (OCT) is now the most widely used modality to …

TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia

S Chen, D Sun, S Zhang, L Xu, N Wang, H Li… - Cell Death & …, 2024 - nature.com
Progressive dysfunction of the retinal pigment epithelium (RPE) and the adjacent
photoreceptor cells in the outer retina plays a pivotal role in the pathogenesis of diabetic …

Next generation therapeutics for retinal neurodegenerative diseases

MB Appell, J Pejavar, A Pasupathy… - Journal of Controlled …, 2024 - Elsevier
Neurodegenerative diseases affecting the visual system encompass glaucoma, macular
degeneration, retinopathies, and inherited genetic disorders such as retinitis pigmentosa …

Chondrocyte‐Targeted Delivery System of Sortase A‐Engineered Extracellular Vesicles Silencing MMP13 for Osteoarthritis Therapy

W Yan, Y Li, S **e, WA Tao, J Hu, H Liu… - Advanced …, 2024 - Wiley Online Library
Targeted drug delivery and the reduction of off‐target effects are crucial for the promising
clinical application of nucleic acid drugs. To address this challenge, a new approach for …

Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Q Zhang, Y Jiang, C Deng, J Wang - Frontiers in Medicine, 2024 - frontiersin.org
In the field of eye health, the profound impact of exercise and physical activity on various
ocular diseases has become a focal point of attention. This review summarizes and …

Interleukin-17A in diabetic retinopathy: the crosstalk of inflammation and angiogenesis

J Li, T Zhao, Y Sun - Biochemical Pharmacology, 2024 - Elsevier
Diabetic retinopathy (DR) is a severe ocular complication of diabetes which can leads to
irreversible vision loss in its late-stage. Chronic inflammation results from long-term …

[HTML][HTML] Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies

BR Giri, D Jakka, MA Sandoval, VR Kulkarni, Q Bao - Pharmaceutics, 2024 - mdpi.com
Eye disorders affect a substantial portion of the global population, yet the availability of
efficacious ophthalmic drug products remains limited. This can be partly ascribed to a …