Immunocytes interact directly with cancer cells in the tumor microenvironment: one coin with two sides and future perspectives

Z Ye, P Cheng, Q Huang, J Hu, L Huang… - Frontiers in …, 2024 - frontiersin.org
The tumor microenvironment is closely linked to the initiation, promotion, and progression of
solid tumors. Among its constitutions, immunologic cells emerge as critical players …

FDA-approved chimeric antigen receptor (CAR)-T cell therapy for different cancers-a recent perspective

R Thirumalaisamy, S Vasuki, SM Sindhu… - Molecular …, 2024 - Springer
Cancer is one of the most prevalent diseases in the world, and their rate of occurence has
been increased in recent decades. Current review article, summarizes the novel treatment …

CAR-T cell therapy in pancreatic and biliary tract cancers: An updated review of clinical trials

K Drougkas, K Karampinos, I Karavolias… - Journal of …, 2024 - Springer
Background Pancreatic and biliary tract cancers are digestive system tumors with dismal
prognosis and limited treatment options. The effectiveness of conventional surgical …

[HTML][HTML] Oncolytic Coxsackievirus B3 Strain PD-H Is Effective Against a Broad Spectrum of Pancreatic Cancer Cell Lines and Induces a Growth Delay in Pancreatic …

A Geisler, B Dieringer, L Elsner, R Klopfleisch… - International Journal of …, 2024 - mdpi.com
Pancreatic cancer is one of the deadliest cancers globally, with limited success from existing
therapies, including chemotherapies and immunotherapies like checkpoint inhibitors for …

[HTML][HTML] Lck Function and Modulation: Immune Cytotoxic Response and Tumor Treatment More Than a Simple Event

JB De Sanctis, JV Garmendia, H Duchová, V Valentini… - Cancers, 2024 - mdpi.com
Simple Summary Lck is an important kinase that plays a key role in the physiological
responses of T lymphocytes as well as in several other tissues such as the lung, intestine …

Unlocking the potential of chimeric antigen receptor T cell engineering immunotherapy: Long road to achieve precise targeted therapy for hepatobiliary pancreatic …

H Gao, L Qu, M Li, X Guan, S Zhang, X Deng… - International Journal of …, 2025 - Elsevier
Innovative therapeutic strategies are urgently needed to address the ongoing global health
concern of hepatobiliary pancreatic malignancies. This review summarizes the latest and …

The role of CD95 in modulating CAR T-cell therapy: Challenges and therapeutic opportunities in oncology

AA Bhat, ASA Altamimi, A Goyal, K Goyal, I Kaur… - International …, 2025 - Elsevier
CAR T cell therapy has revolutionized how we deliver cancer treatment, most notably for
hematologic cancers, by compelling T cells to recognize and kill tumor cells. Nevertheless …

[HTML][HTML] Synthetic Receptor-Based Cell Therapies for Autoimmune Diseases: An Update

M Lachota, R Zagożdżon - Cytotherapy, 2025 - Elsevier
Increasing frequency of autoimmune diseases is one of the major problems in modern
societies. Despite the introduction of new therapeutic agents for autoimmunity over the past …

The molecular evidence behind the adjunct use of anticoagulants and chemotherapy in pancreatic cancer treatment: A new role for anticoagulants?

G Lababidi, N Wahoud, L Ghandour, N Moukalled… - Human Gene, 2024 - Elsevier
Pancreatic cancers include highly aggressive forms of neoplasms, with limited treatment
options and high mortality rates. Recent studies have highlighted various molecular …