Plant-made vaccines against viral diseases in humans and farm animals

H Su, A Van Eerde, E Rimstad, R Bock… - Frontiers in plant …, 2023‏ - frontiersin.org
Plants provide not only food and feed, but also herbal medicines and various raw materials
for industry. Moreover, plants can be green factories producing high value bioproducts such …

The plant viruses and molecular farming: how beneficial they might be for human and animal health?

G Zahmanova, AA Aljabali, K Takova, V Toneva… - International Journal of …, 2023‏ - mdpi.com
Plant viruses have traditionally been studied as pathogens in the context of understanding
the molecular and cellular mechanisms of a particular disease affecting crops. In recent …

[HTML][HTML] The re-emergence of hepatitis E virus in Europe and vaccine development

G Zahmanova, K Takova, V Tonova, T Koynarski… - Viruses, 2023‏ - mdpi.com
Hepatitis E virus (HEV) is one of the leading causes of acute viral hepatitis. Transmission of
HEV mainly occurs via the fecal-oral route (ingesting contaminated water or food) or by …

Plant-derived human vaccines: recent developments

J Stander, S Mbewana, AE Meyers - BioDrugs, 2022‏ - Springer
The idea of producing vaccines in plants originated in the late 1980s. Initially, it was
contemplated that this notion could facilitate the concept of edible vaccines, making them …

Construction of SARS-CoV-2 virus-like particles in plant

KB Moon, JH Jeon, H Choi, JS Park, SJ Park, HJ Lee… - Scientific reports, 2022‏ - nature.com
Abstract The pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) has caused a public health emergency, and research on the development of various …

Plant-derived VLP: a worthy platform to produce vaccine against SARS-CoV-2

F Hemmati, M Hemmati-Dinarvand, M Karimzade… - Biotechnology …, 2022‏ - Springer
After its emergence in late 2019 SARS-CoV-2 was declared a pandemic by the World Health
Organization on 11 March 2020 and has claimed more than 2.8 million lives. There has …

Plant-based expression platforms to produce high-value metabolites and proteins

A Kulshreshtha, S Sharma, CS Padilla… - Frontiers in plant …, 2022‏ - frontiersin.org
Plant-based heterologous expression systems can be leveraged to produce high-value
therapeutics, industrially important proteins, metabolites, and bioproducts. The production …

[HTML][HTML] Combating human viral diseases: will plant-based vaccines be the answer?

S Venkataraman, K Hefferon, A Makhzoum… - Vaccines, 2021‏ - mdpi.com
Molecular pharming or the technology of application of plants and plant cell culture to
manufacture high-value recombinant proteins has progressed a long way over the last three …

[HTML][HTML] Virus-like particles produced in plants: A promising platform for recombinant vaccine development

ES Mardanova, EA Vasyagin, NV Ravin - Plants, 2024‏ - pmc.ncbi.nlm.nih.gov
The capsid proteins of many viruses are capable of spontaneous self-assembly into virus-
like particles (VLPs), which do not contain the viral genome and are therefore not infectious …

High-yield production of chimeric hepatitis E virus-like particles bearing the M2e influenza epitope and receptor binding domain of SARS-CoV-2 in plants using viral …

ES Mardanova, RY Kotlyarov… - International journal of …, 2022‏ - mdpi.com
Capsid protein of Hepatitis E virus (HEV) is capable of self-assembly into virus-like particles
(VLPs) when expressed in Nicotiana benthamiana plants. Such VLPs could be used as …