The invertebrate midintestinal gland (“hepatopancreas”) is an evolutionary forerunner in the integration of immunity and metabolism

T Rőszer - Cell and Tissue Research, 2014 - Springer
The immune system has an impact on the metabolic performance in vertebrates, thus the
metabolic effects of immune cells are receiving intense attention today in the biomedical …

The evolutionary adaptation of shrimp hemocyanin subtypes and the consequences on their structure and functions

J Li, M Zhao, X Zhang, Z Zheng, D Yao, S Yang… - Fish & Shellfish …, 2024 - Elsevier
Hemocyanin is the main respiratory protein of arthropods and is formed by hexameric and/or
oligomeric subunits. Due to changes in the living environment and gene rearrangement …

Structural insights into a functional unit from an immunogenic mollusk hemocyanin

SM Muñoz, G Vallejos-Baccelliere, A Manubens… - Structure, 2024 - cell.com
Mollusk hemocyanins, among the largest known proteins, are used as immunostimulants in
biomedical and clinical applications. The hemocyanin of the Chilean gastropod …

Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non‐specific immunostimulatory effects

S Arancibia, MD Campo, E Nova… - European journal of …, 2012 - Wiley Online Library
Hemocyanins, which boost the immune system of mammals, have been used as carrier‐
adjuvants to promote Ab production against haptens and peptides, as immunostimulants …

[HTML][HTML] Exploring the Antimicrobial Potential and Biofilm Inhibitory Properties of Hemocyanin from Hemifusus pugilinus (Born, 1778)

S Jeyachandran, H Chellapandian, K Park… - International Journal of …, 2023 - mdpi.com
The seafood industry plays a huge role in the blue economy, exploiting the advantage of the
enriched protein content of marine organisms such as shrimps and molluscs, which are …

Gene expression and phenoloxidase activities of hemocyanin isoforms in response to pathogen infections in abalone Haliotis diversicolor

T Yao, MM Zhao, J He, T Han, W Peng, H Zhang… - International journal of …, 2019 - Elsevier
Hemocyanins (Hc), the main protein components of hemolymph in invertebrates, are not
only involved in oxygen transport but also linked to non-specific immune responses. In this …

Molecular cloning and expression of hepatopancreas glutamine synthetase in the Pacific white shrimp, Litopenaeus vannamei, induced by acute hypo-osmotic stress

H Liu, W Sun, B Tan, S Chi, X Dong, Q Yang - Aquaculture, 2012 - Elsevier
Glutamine synthetase (GS) is a key enzyme involved in nitrogen metabolism and glutamine
synthesis. A 1455bp cDNA clone encoding GS was isolated from Litopenaeus vannamei …

Antiviral activity of hemocyanins

P Dolashka, W Voelter - Invertebrate Survival Journal, 2013 - isj.unimore.it
Hemocyanins are giant biological macromolecules acting as oxygen-transporting
glycoproteins. Most of them are respiratory proteins of arthropods and mollusks, but besides …

Hemocyanins in the immunotherapy of superficial bladder cancer

S Arancibia, F Salazar, MI Becker - Bladder Cancer–From Basic …, 2012 - books.google.com
Chemo-and immunotherapeutic approaches have been used to prevent recurrence of
transitional cell carcinoma (TCC), the most common type of superficial bladder cancer …

A new haemocyanin in cuttlefish (Sepia officinalis) eggs: sequence analysis and relevance during ontogeny

A Thonig, M Oellermann, B Lieb, FC Mark - EvoDevo, 2014 - Springer
Background Haemocyanin is the respiratory protein of most of the Mollusca. In cephalopods
and gastropods at least two distinct isoforms are differentially expressed. However, their …