Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder

MH Cho, BD Hobbs, EK Silverman - The Lancet Respiratory …, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …

Genetics of chronic respiratory disease

I Sayers, C John, J Chen, IP Hall - Nature Reviews Genetics, 2024 - nature.com
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

[HTML][HTML] Regenerative metaplastic clones in COPD lung drive inflammation and fibrosis

W Rao, S Wang, M Duleba, S Niroula, K Goller, J **e… - Cell, 2020 - cell.com
Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …

Genetics of COPD

EK Silverman - Annual review of physiology, 2020 - annualreviews.org
Although chronic obstructive pulmonary disease (COPD) risk is strongly influenced by
cigarette smoking, genetic factors are also important determinants of COPD. In addition to …

Elastin in lung development and disease pathogenesis

RP Mecham - Matrix Biology, 2018 - Elsevier
Elastin is expressed in most tissues that require elastic recoil. The protein first appeared
coincident with the closed circulatory system, and was critical for the evolutionary success of …

Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

M Moll, P Sakornsakolpat, N Shrine… - The Lancet …, 2020 - thelancet.com
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …

Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene

MF Ragland, CJ Benway, SM Lutz… - American journal of …, 2019 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …

Biological and genetic mechanisms of COPD, its diagnosis, treatment, and relationship with lung cancer

KH Czarnecka-Chrebelska, D Mukherjee… - Biomedicines, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …

Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Z Fu, J Zhang - Journal of Zhejiang University-SCIENCE B, 2022 - Springer
Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-
inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell …