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Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder
Chronic obstructive pulmonary disease (COPD) is a deadly and highly morbid disease.
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Susceptibility to and heterogeneity of COPD are incompletely explained by environmental …
Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
[HTML][HTML] Regenerative metaplastic clones in COPD lung drive inflammation and fibrosis
Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …
Genetics of COPD
EK Silverman - Annual review of physiology, 2020 - annualreviews.org
Although chronic obstructive pulmonary disease (COPD) risk is strongly influenced by
cigarette smoking, genetic factors are also important determinants of COPD. In addition to …
cigarette smoking, genetic factors are also important determinants of COPD. In addition to …
Elastin in lung development and disease pathogenesis
RP Mecham - Matrix Biology, 2018 - Elsevier
Elastin is expressed in most tissues that require elastic recoil. The protein first appeared
coincident with the closed circulatory system, and was critical for the evolutionary success of …
coincident with the closed circulatory system, and was critical for the evolutionary success of …
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …
Genetic advances in chronic obstructive pulmonary disease. Insights from COPDGene
Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …
is influenced by both genetic and environmental factors. For many years, knowledge of the …
Biological and genetic mechanisms of COPD, its diagnosis, treatment, and relationship with lung cancer
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …
Molecular hydrogen is a promising therapeutic agent for pulmonary disease
Z Fu, J Zhang - Journal of Zhejiang University-SCIENCE B, 2022 - Springer
Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-
inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell …
inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell …