Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery system (SEDDS)

P Baghel, A Roy, S Verma, T Satapathy… - Future Journal of …, 2020 - Springer
Background High lipophilicity and poor aqueous solubility are the endemic problems of new
drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely …

Development of topical/transdermal self-emulsifying drug delivery systems, not as simple as expected

D Van Staden, J Du Plessis, J Viljoen - Scientia pharmaceutica, 2020 - mdpi.com
Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug
delivery system with the sole purpose of improving delivery of highly lipophilic drugs …

[HTML][HTML] Oral formulations for highly lipophilic drugs: impact of surface decoration on the efficacy of self-emulsifying drug delivery systems

M Sandmeier, J Hoeng, SS Jensen… - Journal of Colloid and …, 2025 - Elsevier
Aim To evaluate the impact of the surface decoration of cannabidiol (CBD) loaded self-
emulsifying drug delivery systems (SEDDS) on the efficacy of the formulations to cross the …

Brain targeting of resveratrol through intranasal lipid vesicles labelled with gold nanoparticles: in vivo evaluation and bioaccumulation investigation using computed …

HF Salem, RM Kharshoum, HA Abou-Taleb… - Journal of drug …, 2019 - Taylor & Francis
Resveratrol is a promising neuroprotective agent against neurodegenerative disorders such
as Alzheimer's disease. Resveratrol-loaded transferosomes and nanoemulsions were …

[HTML][HTML] Counterion optimization for hydrophobic ion pairing (HIP): unraveling the key factors

V Claus, M Sandmeier, N Hock, H Spleis… - International Journal of …, 2023 - Elsevier
In the present study, various surfactants were combined with insulin (INS), bovine serum
albumin (BSA) and horseradish peroxidase (HRP) via hydrophobic ion pairing to increase …

Development of a self-emulsifying drug delivery system for optimized topical delivery of clofazimine

D Van Staden, J Du Plessis, J Viljoen - Pharmaceutics, 2020 - mdpi.com
A quality-by-design and characterization approach was followed to ensure development of
self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly …

[HTML][HTML] Replacing PEG-surfactants in self-emulsifying drug delivery systems: Surfactants with polyhydroxy head groups for advanced cytosolic drug delivery

JD Friedl, AM Jörgensen, NMN Le, C Steinbring… - International Journal of …, 2022 - Elsevier
Aim Evaluation of different polyhydroxy surfaces in SEDDS to overcome the limitations
associated with conventional polyethylene glycol (PEG)-based SEDDS surfaces for …

Design of self-emulsifying oral delivery systems for semaglutide: reverse micelles versus hydrophobic ion pairs

M Sandmeier, F Ricci, D To, S Lindner… - Drug Delivery and …, 2024 - Springer
It was the aim of this study to evaluate the potential of reverse micelles (RM) and
hydrophobic ion pairs (HIP) for incorporation of semaglutide into self-emulsifying oral drug …

Recent progress in self-emulsifying drug delivery systems: a systematic patent review (2011-2020)

PSL Ruiz, MR Serafini, IA Alves… - Critical Reviews™ in …, 2022 - dl.begellhouse.com
Self-emulsifying drug delivery systems (SEDDS) are lipid-based isotropic mixtures that
enhance the bioavailability of poorly water-soluble drugs and reduce the possible side …

[HTML][HTML] SEDDS-loaded mucoadhesive fiber patches for advanced oromucosal delivery of poorly soluble drugs

JD Friedl, M Walther, PK Vestweber, J Wächter… - Journal of Controlled …, 2022 - Elsevier
To date, buccal administration of lipophilic drugs is still a major challenge due to their poor
solubility in saliva and limited penetration into mucosal tissues. To overcome these …