Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …

Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of
amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since …

Amyloid fibrils, which are closely associated with various neurodegenerative diseases, are
the final products in many protein aggregation pathways. The identification of fibrils at low …

Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …

The small molecule thioflavin T (ThT) is a defining probe for the identification and
mechanistic study of amyloid fiber formation. As such, ThT is fundamental to investigations of …

We report on the direct observation of a nanostructural transformation from a twisted ribbon
to a helical ribbon in supramolecular assemblies of peptide amphiphiles. Using cryogenic …

Selective degradation of extracellular pathogenic proteins by degrader technologies such as
lysosome-targeting chimeras (LYATCs) provides promising therapeutic strategies for" …

Amyloid fibrils are a pathologically and functionally relevant state of protein folding, which is
generally accessible to polypeptide chains and differs fundamentally from the globular state …

Amyloid fiber formation is a key event in many misfolding disorders. The ability to monitor the
kinetics of fiber formation and other prefibrillar assemblies is therefore crucial for …

Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …