Viral capsids are often regarded as inert structural units, but in actuality they display
fascinating dynamics during different stages of their life cycle. With the advent of single …

Single-entity (or digital) measurements enhance sensitivity (10-to 100-fold improvement)
and uncover heterogeneity within a population (one event in 100 to 10,000). Many biological …

As analytical interests have become targeted on sensitive detection of objects of a tiny size
and volume, various fields in analytical chemistry have been developed to overcome …

Phase separation of viral biopolymers is a key factor in the formation of cytoplasmic viral
inclusions, known as sites of virus replication and assembly. This review describes the …

Self-assembly of supramolecular complexes such as viral capsids occurs prominently in
nature. Nonetheless, the mechanisms underlying these processes remain poorly …

Hepatitis B virus (HBV) is an endemic, chronic virus that leads to 800000 deaths per year.
Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies …

There are∼ 1030 possible intermediates on the assembly path from hepatitis B capsid
protein dimers to the 120-dimer capsid. If every intermediate was tested, assembly would …

Computational modeling of assembly is challenging for many systems, because their
timescales can vastly exceed those accessible to simulations. This article describes the …

Viral structural proteins are emerging as effective targets for new antivirals. In a viral
lifecycle, the capsid must assemble, disassemble, and respond to host proteins, all at the …

Development of antiviral molecules that bind virion is a strategy that remains in its infancy,
and the details of their mechanisms are poorly understood. Here we investigate the behavior …