[HTML][HTML] The hammer and the dance of cell cycle control
Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …
Regulation of mammalian totipotency: a molecular perspective from in vivo and in vitro studies
T Nakatani, ME Torres-Padilla - Current Opinion in Genetics & …, 2023 - Elsevier
Highlights•Cellular models can recapitulate some aspects of embryonic genome
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …
activation.•Multiple factors regulate embryonic genome activation.•Several types of totipotent …
[HTML][HTML] Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
M Yang, H Yu, X Yu, S Liang, Y Hu, Y Luo, Z Izsvák… - Cell Stem Cell, 2022 - cell.com
Totipotent cells have more robust developmental potency than any other cell types, giving
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …
rise to both embryonic and extraembryonic tissues. Stable totipotent cell cultures and …
p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models
In mammalian embryos, proper zygotic genome activation (ZGA) underlies totipotent
development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is …
development. Double homeobox (DUX)-family factors participate in ZGA, and mouse Dux is …
[HTML][HTML] Recapitulating early human development with 8C-like cells
X Yu, S Liang, M Chen, H Yu, R Li, Y Qu, X Kong… - Cell reports, 2022 - cell.com
In human embryos, major zygotic genome activation (ZGA) initiates at the eight-cell (8C)
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …
stage. Abnormal ZGA leads to developmental defects and even contributes to the failure of …
DNA replication fork speed underlies cell fate changes and promotes reprogramming
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly
characterized. In the present study, we employed DNA fiber analysis to investigate how …
characterized. In the present study, we employed DNA fiber analysis to investigate how …
CTCF is a barrier for 2C-like reprogramming
Totipotent cells have the ability to generate embryonic and extra-embryonic tissues.
Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like …
Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like …
DUX4 role in normal physiology and in FSHD muscular dystrophy
E Mocciaro, V Runfola, P Ghezzi, M Pannese… - Cells, 2021 - mdpi.com
In the last decade, the sequence-specific transcription factor double homeobox 4 (DUX4)
has gone from being an obscure entity to being a key factor in important physiological and …
has gone from being an obscure entity to being a key factor in important physiological and …
A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation
Transition from maternal to embryonic transcriptional control is crucial for embryogenesis.
However, alternative splicing regulation during this process remains understudied. Using …
However, alternative splicing regulation during this process remains understudied. Using …
The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced …
DC Hamm, EM Paatela, SR Bennett, CJ Wong… - PLoS …, 2023 - journals.plos.org
Translational control is critical for cell fate transitions during development, lineage
specification, and tumorigenesis. Here, we show that the transcription factor double …
specification, and tumorigenesis. Here, we show that the transcription factor double …