Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

The p21 Rho-family of small GTPases are master regulators of actin cytoskeleton
rearrangements. Their functions have been well characterized in terms of their effects toward …

Intestinal epithelial cells are exposed to both innocuous and pathogenic microbes, which
need to be distinguished to mount an effective immune response. To understand the …

During mitosis, cells undergo symmetrical cell division, while oocyte meiotic maturation
undergoes two consecutive, asymmetric divisions that generate a totipotent haploid oocyte …

Background: Most of the effects of statins can be explained by pleiotropic effects
independent of their lowering of serum cholesterol; in some cases, these effects have been …

RASopathies, a family of disorders characterized by cardiac defects, defective growth, facial
dysmorphism, variable cognitive deficits and predisposition to certain malignancies, are …

Abstract Development of the central nervous system (CNS) is a complex, dynamic process
that involves a precisely orchestrated sequence of genetic, environmental, biochemical, and …

Immunity could be viewed as the common factor in neurodevelopmental disorders and
cancer. The immune and nervous systems coevolve as the embryo develops. Immunity can …

Peptide neuromodulators are released from a unique organelle: the dense-core vesicle.
Dense-core vesicles are generated at the trans-Golgi and then sort cargo during maturation …