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The cGAS–STING pathway as a therapeutic target in inflammatory diseases
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
evolved for defence against viruses. Once triggered, these sensors stimulate the production …
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
Mitochondrial DNA in inflammation and immunity
Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …
from energy production and metabolism to cell death and inflammation. Despite this …
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS–STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice
M Yan, Y Li, Q Luo, W Zeng, X Shao, L Li, Q Wang… - Cell Death …, 2022 - nature.com
Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently
lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …
lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …
[HTML][HTML] Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …
Immune cells and immunotherapy for cardiac injury and repair
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …
significant advances, a full understanding of why the heart fails to fully recover function after …
cGAS in action: Expanding roles in immunity and inflammation
BACKGROUND The life of any organism depends on the ability of cells to accurately
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …
recognize and eliminate harmful microbes. To detect the immense repertoire of pathogenic …
[HTML][HTML] The cGAS–STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
exert essential regulatory function in microbial-and onco-immunology through the induction …
exert essential regulatory function in microbial-and onco-immunology through the induction …