WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

Snail1 is the founding member of the Snail superfamily of zinc-finger transcription factors,
which also includes Snail2 (Slug) and Snail3 (Smuc). The superfamily is involved in cell …

Myelin sheaths provide critical functional and trophic support for axons in white matter tracts
of the brain. Oligodendrocyte precursor cells (OPCs) have extraordinary metabolic …

Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …

β-Catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell
factor or lymphoid enhancer factor family members, and transactivates its target genes. In …

Recent revelations that the canonical Wnt signaling pathway promotes postnatal bone
accrual are major advances in our understanding of skeletal biology and bring tremendous …

Mutations in the adenomatous polyposis coli or β-catenin gene lead to cytosolic
accumulation of β-catenin and, subsequently, to increased transcriptional activity of the β …

ABSTRACT β-catenin is a multifunctional protein found in three cell compartments: the
plasma membrane, the cytoplasm and the nucleus. The cell has developed elaborate ways …

Wnt growth factors regulate a variety of developmental processes by altering specific gene
expression patterns. In vertebrates β‐catenin acts as transcriptional activator, which is …

Constitutive activation of the Wnt signaling pathway is a root cause of many colon cancers,,.
Activation of this pathway is caused by genetic mutations that stabilize the β-catenin protein …