NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

Accumulation of neuronal α-synuclein is a prominent feature in Parkinson's disease. More
recently, such abnormal protein aggregation has been reported to spread from cell to cell …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Background: Stroke is a leading cause of adult disability that can severely compromise the
quality of life of patients, yet no effective medication currently exists to accelerate …

Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs)
involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later …

Stat6 is known to drive macrophage M2 polarization. However, how macrophage
polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is …

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally
related proteins that transduces signals from members of TNFR superfamily and various …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …