Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

S Qian, O Golubnitschaja, X Zhan - Epma Journal, 2019 - Springer
A strong relationship exists between tumor and inflammation, which is the hot point in cancer
research. Inflammation can promote the occurrence and development of cancer by …

The influence of tumor microenvironment on immune escape of melanoma

A Simiczyjew, E Dratkiewicz, J Mazurkiewicz… - International Journal of …, 2020 - mdpi.com
The low efficiency of currently-used anti-cancer therapies poses a serious challenge,
especially in the case of malignant melanoma, a cancer characterized by elevated …

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

Z Zhang, X Tian, JY Lu, K Boit, J Ablaeva, FT Zakusilo… - Nature, 2023 - nature.com
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …

[HTML][HTML] Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR …

X Zheng, W Li, H Xu, J Liu, L Ren, Y Yang, S Li… - … Pharmaceutica Sinica B, 2021 - Elsevier
Glioblastoma multiforme (GBM) in the central nervous system is the most lethal advanced
glioma and currently there is no effective treatment for it. Studies of sinomenine, an alkaloid …

Inflammation and metabolism in cancer cell—mitochondria key player

M Neagu, C Constantin, ID Popescu, D Zipeto… - Frontiers in …, 2019 - frontiersin.org
Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …

Applications of nanosized-lipid-based drug delivery systems in wound care

AM Matei, C Caruntu, M Tampa, SR Georgescu… - Applied Sciences, 2021 - mdpi.com
Impaired wound healing is an encumbering public health issue that increases the demand
for develo** new therapies in order to minimize health costs and enhance treatment …

Cannabinoids in the pathophysiology of skin inflammation

C Scheau, IA Badarau, LG Mihai, AE Scheau… - Molecules, 2020 - mdpi.com
Cannabinoids are increasingly-used substances in the treatment of chronic pain, some
neuropsychiatric disorders and more recently, skin disorders with an inflammatory …

Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and cannabidiol against non-melanoma skin cancer

N Hasan, M Imran, A Sheikh, N Tiwari, A Jaimini… - Environmental …, 2023 - Elsevier
Non-melanoma skin cancer is one of the most common malignancies reported around the
globe. Current treatment therapies fail to meet the desired therapeutic efficacy due to high …

[HTML][HTML] Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

X Liu, L Yin, S Shen, Y Hou - Genes & Diseases, 2023 - Elsevier
Chronic inflammation caused by persistent infections and metabolic disorders is thought to
contribute to the increased cancer risk and the accelerated cancer progression. Oppositely …

Pyrimidine-5-carbonitrile derivatives as sprout for CQDs proveniences: antitumor and anti-inflammatory potentiality

HB Ahmed, MM Mikhail, AEM Abdallah, M El-Shahat… - Bioorganic …, 2023 - Elsevier
A comparative study is proposed to show the effect of variation in the heteroatoms in the
main skeleton of CQDs proveniences, on their affinity for nucleation of CQDs, as anti …