Highlights•Hemagglutinin stalk-reactive monoclonal antibodies are able to neutralize
divergent influenza virus strains.•Stalk-reactive antibodies are currently being tested in …

Neutralizing antibodies (NAbs) typically play a key role in controlling viral infections and
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …

ABSTRACT A window of opportunity for immune responses to extinguish human
immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through …

Antibodies are widely considered to be a frequent primary and often mechanistic correlate of
protection of approved vaccines; thus evaluating the antibody response is of critical …

Preexisting cross-reactive antibodies have been implicated in both protection and
pathogenesis during subsequent infections with different dengue virus (DENV) serotypes …

In vivo, the activity of antibodies relies critically on properties of both the variable domain,
responsible for antigen recognition, and the constant domain, responsible for innate immune …

Current influenza vaccines elicit Abs to the hemagglutinin and neuraminidase envelope
proteins. Due to antigenic drift, these vaccines must be reformulated annually to include the …

The complement system is a key component of innate immunity which readily responds to
invading microorganisms. Activation of the complement system typically occurs via three …

HIV-specific broadly neutralizing antibodies (bNAbs) confer protection after passive
immunization, but the immunological mechanisms that drive their development are poorly …

The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of
pathogenic lentiviral infection through both innate and adaptive mechanisms. We studied …