Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy

MJ Saadh, MV Mikhailova, S Rasoolzadegan… - European Journal of …, 2023 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) therapy has become an emerging
therapeutic modality for the treatment of inflammatory bowel disease (IBD), given their …

[HTML][HTML] Mesenchymal stem/stromal cells for rheumatoid arthritis treatment: an update on clinical applications

M Lopez-Santalla, R Fernandez-Perez, MI Garin - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects the lining of
the synovial joints leading to stiffness, pain, inflammation, loss of mobility, and erosion of …

Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages

LC Shanley, OR Mahon, DJ Kelly, A Dunne - Acta Biomaterialia, 2021 - Elsevier
Tissue healing and regeneration is a complex, choreographed, spatiotemporal process
involving a plethora of cell types, the activity of which is stringently regulated in order for …

Human umbilical cord mesenchymal stem cells ameliorate colon inflammation via modulation of gut microbiota-SCFAs-immune axis

A Liu, X Liang, W Wang, C Wang, J Song, J Guo… - Stem Cell Research & …, 2023 - Springer
Background Inflammatory bowel disease (IBD) is a global health problem in which gut
microbiota dysbiosis plays a pivotal pathogenic role. Mesenchymal stem cells (MSCs) …

Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed …

Y Zhang, J Chen, H Fu, S Kuang, F He… - International journal of …, 2021 - nature.com
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …

Drug delivery to the inflamed intestinal mucosa–targeting technologies and human cell culture models for better therapies of IBD

O Hartwig, MAS Boushehri, KS Shalaby… - Advanced drug delivery …, 2021 - Elsevier
Current treatment strategies for inflammatory bowel disease (IBD) seek to alleviate the
undesirable symptoms of the disorder. Despite the higher specificity of newer generation …

[HTML][HTML] Management of rheumatoid arthritis: possibilities and challenges of mesenchymal stromal/stem cell-based therapies

Y Shimizu, EH Ntege, C Azuma, F Uehara, T Toma… - Cells, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a highly prevalent, chronic, and progressive autoimmune
disorder primarily affecting joints and muscles. The associated inflammation, pain, and …

Exploiting urine-derived induced pluripotent stem cells for advancing precision medicine in cell therapy, disease modeling, and drug testing

X Yin, Q Li, Y Shu, H Wang, B Thomas… - Journal of Biomedical …, 2024 - Springer
The field of regenerative medicine has witnessed remarkable advancements with the
emergence of induced pluripotent stem cells (iPSCs) derived from a variety of sources …

Urine-derived stem cells: promising advancements and applications in regenerative medicine and beyond

Y Sun, H Zhao, S Yang, G Wang, L Zhu, C Sun, Y An - Heliyon, 2024 - cell.com
Currently, stem cells are a prominent focus of regenerative engineering research. However,
due to the limitations of commonly used stem cell sources, their application in therapy is …

[HTML][HTML] Application of genipin-crosslinked small intestine submucosa and urine-derived stem cells for the prevention of intrauterine adhesion in a rat model

YT Song, L Dong, JG Hu, PC Liu, YL Jiang… - Composites Part B …, 2023 - Elsevier
As a major cause for recurrent miscarriage and secondary infertility, intrauterine adhesion
(IUA) is characterized by partial or total obliteration of the uterine cavity and/or cervical canal …