SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …

Research and medical genomics require comprehensive, scalable methods for the
discovery of novel disease targets, evolutionary drivers and genetic markers with clinical …

Mutations enhancing the kinase activity of leucine-rich repeat kinase-2 (LRRK2) cause
Parkinson's disease (PD) and therapies that reduce LRRK2 kinase activity are being tested …

Parkinson's disease (PD) is a multi-attribute neurodegenerative disorder combining motor
and nonmotor symptoms without well-defined diagnostic clinical markers. The presence of …

Parkinson's disease (PD) is a devastating disease associated with accumulation of α-
synuclein (α-Syn) within dopaminergic neurons, leading to neuronal death. PD is …

Parkinson's disease (PD) is a neurodegenerative disease with both genetic and sporadic
origins. In this study, we investigated the electrophysiological properties, synaptic activity …

Progress in develo** disease-modifying therapies in Parkinson's disease (PD) can only
be achieved through reliable objective markers that help to identify subjects at risk. This …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, globally
affecting men and women at an exponentially growing rate, with currently no cure. Disease …