Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …

Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection,
and it probably represents a pattern of response by the immune system to injury. A hyper …

A sufficient response of neutrophil granulocytes stimulated by interleukin (IL)-8 is vital during
systemic inflammation, for example, in sepsis or severe trauma. Moreover, IL-8 is clinically …

Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …

Introduction Biomarkers can be useful for identifying or ruling out sepsis, identifying patients
who may benefit from specific therapies or assessing the response to therapy. Methods We …

Background: Sepsis is a deadly immunological disorder and its pathophysiology is still
poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory …

The concept of 'Compensatory anti-inflammatory response syndrome'(CARS) was proposed
in 1997 by Roger Bone (1941–1997) to qualify the consequences of the counter-regulatory …

Rationale: Although the outcome of sepsis benefits from the prompt administration of
appropriate antibiotics on correct diagnosis, the assessment of infection in critically ill …

Sepsis is one of the leading causes of mortality among critically ill patients globally.
According to WHO report 2018, it is estimated to affect beyond 30 million people worldwide …

Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The
available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64 …