The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

Abstract CARD protein–BCL-10–MALT1 (CBM) signalosomes are multiprotein signalling
platforms that control immune and inflammatory pathways in most tissues. After exposure to …

Antigen receptor signalling activates the canonical NF-κB pathway via the CARD11/BCL10/
MALT1 (CBM) signalosome involving key, yet ill-defined roles for linear ubiquitination. The …

The caspase recruitment domain family member 11 (CARD11 or CARMA1)—B cell
CLL/lymphoma 10 (BCL10)—MALT1 paracaspase (MALT1)[CBM] signalosome complex …

The paracaspase MALT1 has a central role in the activation of lymphocytes and other
immune cells including myeloid cells, mast cells and NK cells. MALT1 activity is required not …

The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is a protease and scaffold
protein essential in propagating B-cell receptor (BCR) signaling to NF-κB. The …

MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling
pathways. With MALT1A and MALT1B two conserved splice variants exist and we …

The scaffold proteins CARMA1-3 (encoded by the genes CARD11,-14 and-10) and CARD9
play major roles in signaling downstream of receptors with immunoreceptor tyrosine …

CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte
activation during the adaptive immune response. Somatic mutations in CARD11 are …

Introduction MALT1 is the only human paracaspase, a protease with unique cleavage
activity and substrate specificity. As a key regulator of immune responses, MALT1 has …