Cell adhesion proteins play critical roles in positioning cells during development,
segregating cells into distinct tissue compartments and in maintaining tissue integrity. The …

The biological catch bond is fascinating and counterintuitive. When an external force is
applied to a catch bond, either in vivo or in vitro, the bond resists breaking and becomes …

Classical cadherin Ca2+-dependent cell–cell adhesion proteins play key roles in
embryogenesis and in maintaining tissue integrity. Cadherins mediate robust adhesion by …

Catch bonds, whose lifetimes are prolonged by force, have been observed in selectin-ligand
interactions and other systems. Several biophysical models have been proposed to explain …

Lifetimes of bound states of protein complexes or biomolecule folded states typically
decrease when subject to mechanical force. However, a plethora of biological systems …

Hydrodynamic dimension (HD) is the primary indicator of the size of bioconjugated particles
and biomolecules. It is an important parameter in the study of solid–liquid two-phase …

Catch-binding is a counterintuitive phenomenon in which the lifetime of a receptor/ligand
bond increases when a force is applied to break the bond. Several mechanisms have been …

Molecular biomechanics includes two themes: the study of mechanical aspects of
biomolecules and the study of molecular biology of the cell using mechanical tools. The two …

The proposed model demonstrates the allosteric role of the two-domain region of the
receptor protein in the increased lifetimes of biological receptor/ligand bonds subjected to …

Cells bind to each other and to surfaces using complementary receptor-ligand pairs as an
essential part of their function. The mechanical forces that build up on these bonds was …