Microfluidics for drug development: from synthesis to evaluation
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …
delivery, and drug evaluation. Compared with conventional drug development procedures …
Lung-on-a-chip: the future of respiratory disease models and pharmacological studies
Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …
cellular architecture and physiological environment of an organ, have been developed and …
Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane
P Zamprogno, S Wüthrich, S Achenbach… - Communications …, 2021 - nature.com
The air-blood barrier with its complex architecture and dynamic environment is difficult to
mimic in vitro. Lung-on-a-chips enable mimicking the breathing movements using a thin …
mimic in vitro. Lung-on-a-chips enable mimicking the breathing movements using a thin …
3D lung-on-chip model based on biomimetically microcurved culture membranes
A comparatively straightforward approach to accomplish more physiological realism in
organ-on-a-chip (OoC) models is through substrate geometry. There is increasing evidence …
organ-on-a-chip (OoC) models is through substrate geometry. There is increasing evidence …
[HTML][HTML] Journey of organ on a chip technology and its role in future healthcare scenario
Organ on a chip refers to microengineered biomimetic system which reflects structural and
functional characteristics of human tissue. It involves biomaterial technology, cell biology …
functional characteristics of human tissue. It involves biomaterial technology, cell biology …
[HTML][HTML] Airway-on-a-chip: designs and applications for lung repair and disease
The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …
Recent advances of biosensor-integrated organ-on-a-chip technologies for diagnostics and therapeutics
Conventional preclinical evaluation implemented in 2D monolayer cultures falls short with
multiorgan interactions, while animal systems lack the specificity of the human species …
multiorgan interactions, while animal systems lack the specificity of the human species …
A new immortalized human alveolar epithelial cell model to study lung injury and toxicity on a breathing lung-on-chip system
The evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the
investigation of complex disease pathomechanisms, are increasingly relying on in vitro lung …
investigation of complex disease pathomechanisms, are increasingly relying on in vitro lung …
Develo** organs‐on‐chips for biomedical applications
In recent years, organs‐on‐chips have been arousing great interest for their bionic and
stable construction of crucial human organs in vitro. Compared with traditional animal …
stable construction of crucial human organs in vitro. Compared with traditional animal …
[HTML][HTML] Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery
T Ahmed - Biosensors and Bioelectronics: X, 2022 - Elsevier
The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …