Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Patients with mammographically dense breast tissue have a greatly increased risk of
develo** breast cancer. Dense breast tissue contains more stromal collagen, which …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system
associated with a median survival time of 15 months, even with aggressive therapy. This …

Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) are related tyrosine
kinases that have important cellular functions, primarily through regulation of the …