The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of
elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We …

Cancer is a multifactorial disease. Aberrant functioning of the underlying complex signaling
network that orchestrates cellular response to external or internal cues governs incidence …

Intra-tumor heterogeneity contributes to treatment failure and poor survival in urothelial
bladder carcinoma (UBC). Analyzing transcriptome from a UBC cohort, we report that intra …

Metastasis remains an unsolved clinical challenge. Two crucial features of metastasizing
cancer cells are (a) their ability to dynamically move along the epithelial–hybrid …

Increasing evidence has revealed that cancer cells undergoing an intermediate state, partial
epithelial mesenchymal transition (p‐EMT), tend to metastasize rather than complete EMT …

Computational tools addressing various components of design–build–test–learn (DBTL)
loops for the construction of synthetic genetic networks exist but do not generally cover the …

We consider two types of models of regulatory network dynamics: Boolean maps and
systems of switching ordinary differential equations. Our goal is to construct all models in …

Phenotypic heterogeneity is a hallmark of aggressive cancer behaviour and a clinical
challenge. Despite much characterisation of this heterogeneity at a multi-omics level in …

We present a simple nonlinear model describing the population dynamics of cancerous,
healthy, and effector cells submitted to ionizing radiation. We examine the situations in …

Mathematical modeling of the emergent dynamics of gene regulatory networks (GRN) faces
a double challenge of (a) dependence of model dynamics on parameters, and (b) lack of …