Cancer neuroscience: State of the field, emerging directions
The nervous system governs both ontogeny and oncology. Regulating organogenesis
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
during development, maintaining homeostasis, and promoting plasticity throughout life, the …
The neuroscience of cancer
The nervous system regulates tissue stem and precursor populations throughout life.
Parallel to roles in development, the nervous system is emerging as a critical regulator of …
Parallel to roles in development, the nervous system is emerging as a critical regulator of …
Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis
Tumour innervation is associated with worse patient outcomes in multiple cancers,, which
suggests that it may regulate metastasis. Here we observed that highly metastatic mouse …
suggests that it may regulate metastasis. Here we observed that highly metastatic mouse …
Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion
The meninges are densely innervated by nociceptive sensory neurons that mediate pain
and headache,. Bacterial meningitis causes life-threatening infections of the meninges and …
and headache,. Bacterial meningitis causes life-threatening infections of the meninges and …
Cancer metastasis: molecular mechanisms and clinical perspectives
Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …
shapes the course of disease for cancer patients and commonly determines its lethal …
The neural addiction of cancer
C Magnon, H Hondermarck - Nature Reviews Cancer, 2023 - nature.com
The recently uncovered key role of the peripheral and central nervous systems in controlling
tumorigenesis and metastasis has opened a new area of research to identify innovative …
tumorigenesis and metastasis has opened a new area of research to identify innovative …
Beyond genetics: driving cancer with the tumour microenvironment behind the wheel
Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …
fuelled by studies showing that ageing tissues are often riddled with clones of complex …
The neurotransmitter calcitonin gene-related peptide shapes an immunosuppressive microenvironment in medullary thyroid cancer
Y Hou, B Lin, T Xu, J Jiang, S Luo, W Chen… - Nature …, 2024 - nature.com
Neurotransmitters are key modulators in neuro-immune circuits and have been linked to
tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor …
tumor progression. Medullary thyroid cancer (MTC), an aggressive neuroendocrine tumor …
Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression
Cancer-associated fibroblasts (CAF) and nerves, components of the tumor
microenvironment, have each been shown to directly promote gastrointestinal cancers …
microenvironment, have each been shown to directly promote gastrointestinal cancers …
Crosstalk between the nervous system and tumor microenvironment: Functional aspects and potential therapeutic strategies
L Wang, J Ge, H Han, Y Jia, Y Qin - Cancer letters, 2024 - Elsevier
Recent advancements in understanding the tumor microenvironment (TME) have
highlighted the critical role of the nervous system in cancer progression. This review …
highlighted the critical role of the nervous system in cancer progression. This review …