Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers

S Nooraei, H Bahrulolum, ZS Hoseini… - Journal of …, 2021 - Springer
Virus-like particles (VLPs) are virus-derived structures made up of one or more different
molecules with the ability to self-assemble, mimicking the form and size of a virus particle but …

Virus-like particle vaccinology, from bench to bedside

MO Mohsen, MF Bachmann - Cellular & molecular immunology, 2022 - nature.com
Virus-like particles (VLPs) have become key tools in biology, medicine and even
engineering. After their initial use to resolve viral structures at the atomic level, VLPs were …

Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …

Biomaterial‐based in situ cancer vaccines

Y Bo, H Wang - Advanced Materials, 2024 - Wiley Online Library
Cancer immunotherapies have reshaped the paradigm for cancer treatment over the past
decade. Among them, therapeutic cancer vaccines that aim to modulate antigen‐presenting …

Advancements in prophylactic and therapeutic nanovaccines

P Bhardwaj, E Bhatia, S Sharma, N Ahamad… - Acta Biomaterialia, 2020 - Elsevier
Vaccines activate suitable immune responses to fight against diseases but can possess
limitations such as compromised efficacy and immunogenic responses, poor stability, and …

Chemical strategies to boost cancer vaccines

WH Li, YM Li - Chemical reviews, 2020 - ACS Publications
Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

[HTML][HTML] Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment

J Li, DJ Burgess - Acta Pharmaceutica Sinica B, 2020 - Elsevier
The complex tumor microenvironment is a most important factor in cancer development. The
biological microenvironment is composed of a variety of barriers including the extracellular …

The 3Ds in virus‐like particle based‐vaccines: “Design, Delivery and Dynamics

MO Mohsen, G Augusto… - Immunological reviews, 2020 - Wiley Online Library
Vaccines need to be rationally designed in order be delivered to the immune system for
maximizing induction of dynamic immune responses. Virus‐like particles (VLPs) are ideal …

Cowpea mosaic virus stimulates antitumor immunity through recognition by multiple MYD88-dependent toll-like receptors

C Mao, V Beiss, J Fields, NF Steinmetz, S Fiering - Biomaterials, 2021 - Elsevier
Cowpea mosaic virus (CPMV), a non-enveloped plant virus, and empty CPMV (eCPMV), a
virus-like particle (VLP) composed of CPMV capsid without nucleic acids, are potent in situ …

Virus‐like particles for vaccination against cancer

MO Mohsen, DE Speiser, A Knuth… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Active immunotherapy of cancer aims to treat the disease by inducing effective cellular and
humoral immune responses. Virus‐like particle‐based vaccines have evolved dramatically …