When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

Advances in the chemical synthesis of C-pyranosides/furanosides are summarized, covering
the literature from 2000 to 2016. The majority of the methods take advantage of the …

Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …

Fluorescent nucleoside analogues (FNAs) are structurally diverse mimics of the natural
essentially non-fluorescent nucleosides which have found numerous applications in probing …

While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed
hydrolysis of the nucleosidic bond, their C-analogues are much more stable. Several C …

Fluorescence labeling and probing are fundamental techniques for nucleic acid analysis
and quantification. However, new fluorescent probes and approaches are urgently needed …

To broaden the applicability of chemically modified DNAs in nano-and biotechnology,
material science, sensor development, and molecular recognition, strategies are required for …

Synthetic biology seeks to probe fundamental aspects of biological form and function by
construction [ie,(re) synthesis] rather than deconstruction (analysis). In this sense, biological …

We describe the design, synthesis, and properties of nucleoside monomers in which the
DNA base is replaced by fluorescent hydrocarbons and heterocycles, and the assembly of …

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …