The field of prebiotic chemistry has been dedicated over decades to finding abiotic routes
towards the molecular components of life. There is nowadays a handful of prebiotically …

Homochirality is a signature of life on Earth, yet its origins remain an unsolved puzzle.
Achieving homochirality is essential for a high-yielding prebiotic network capable of …

The Perseverance rover has collected seven oriented samples of sedimentary rocks, all
likely older than the oldest signs of widespread life on Earth, at the exposed base of the …

The relationship between genetic molecules and metabolism is one of the longest-standing
problems for the origin of life. A central molecule within early metabolism is the coenzyme …

An electrochemically initiated heteroaryltrifluoromethylation of allylic amines was developed.
The cascade reaction involved the anodic oxidation of Langlois reagent (CF3SO2Na) to …

Charge separation is one of the most common consequences of the absorption of UV light
by DNA. Recently, it has been shown that this process can enable efficient self-repair of …

RNA is a molecule that can both store genetic information and perform catalytic reactions.
This observed dualism places RNA into the limelight of concepts about the origin of life. The …

Prussian blue (PB)-based nanomedicines constructed from metal ion coordination remain
restricted due to their limited therapeutic properties, and their manifold evaluation complexity …

The formose reaction is often cited as a prebiotic source of sugars and remains one of the
most plausible forms of autocatalysis on the early Earth. Herein, we investigated how …

Among the many prebiotic phosphorylation chemistries investigated, diamidophosphate
(DAP) has shown promising potential for nucleoside phosphorylation. Herein, we show that …