Osteomyelitis, or inflammation of bone, is most commonly caused by invasion of bacterial
pathogens into the skeleton. Bacterial osteomyelitis is notoriously difficult to treat, in part …

Polymethyl methacrylate (PMMA)-based bone cement is a biomaterial that has been used
over the last 50 years to stabilize hip and knee implants or as a bone filler. Although PMMA …

Use of articular antibiotic-eluting cement spacers during two-stage revision arthroplasty for
prosthetic joint infection (PJI) is a long-established and proven adjunctive technique during …

Infection and loosening of implants after joint replacement are the complications that have
troubled patients and doctors for a long time. To prevent such complications, we selected …

High mechanical property especially the exorbitant elastic modulus is the common
complication of the clinical polymethylmethacrylate (PMMA) bone cement which will …

Recommendation: Articulating spacers appear to provide better range of motion and less
functional limitations to the patients undergoing resection arthroplasty and should be used …

Advances in the design of potential bone‐selective drugs for the treatment of various bone‐
related diseases are creating exciting new directions for multiple unmet medical needs. For …

PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a
fluid mixture, which hardens over time. The problem of infected prosthesis could be solved …

Soft tissue defects resulting from trauma and musculoskeletal infections can complicate
surgical treatment. Appropriate temporary coverage of these defects is essential to achieve …

This review evaluates the decision-making framework for using antibiotic-loaded cement
(ALC) in the management of prosthetic joint infection (PJI). Drawing on available literature …