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Renal cell carcinoma of variant histology: New biologic understanding leads to therapeutic advances
Renal cell carcinoma (RCC) is one of the 10 most commonly diagnosed solid tumors. Most
RCCs are histologically defined as clear cell, comprising approximately 75% of diagnoses …
RCCs are histologically defined as clear cell, comprising approximately 75% of diagnoses …
[HTML][HTML] A framework for target discovery in rare cancers
While large-scale functional genetic screens have uncovered numerous cancer
dependencies, rare cancers are poorly represented in such efforts and the landscape of …
dependencies, rare cancers are poorly represented in such efforts and the landscape of …
Single-cell DNA replication dynamics in genomically unstable cancers
Dysregulated DNA replication is both a cause and a consequence of aneuploidy, yet the
dynamics of DNA replication in aneuploid cell populations remains understudied. We …
dynamics of DNA replication in aneuploid cell populations remains understudied. We …
Haplotype-resolved karyotype construction from Hi-C data using refLinker
Genomic characterization has revealed widespread structural complexity in cancer
karyotypes, however shotgun sequencing cannot resolve genomic rearrangements with …
karyotypes, however shotgun sequencing cannot resolve genomic rearrangements with …
Single-Cell Replication Timing and Proliferation Dynamics of Genomically Unstable Cancers
A Weiner - 2024 - search.proquest.com
Cancer is inherently a disease of uncontrolled proliferation where dysregulated DNA
replication is both a cause and a consequence of aneuploidy. Unfortunately, DNA …
replication is both a cause and a consequence of aneuploidy. Unfortunately, DNA …