The highly diverse antiphage defence systems of bacteria
H Georjon, A Bernheim - Nature Reviews Microbiology, 2023 - nature.com
Bacteria and their viruses have coevolved for billions of years. This ancient and still ongoing
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …
Defining the expanding mechanisms of phage-mediated activation of bacterial immunity
Due to recent discovery efforts, over 100 immune systems encoded by bacteria that
antagonize bacteriophage (phage) replication have been uncovered. These systems …
antagonize bacteriophage (phage) replication have been uncovered. These systems …
Structural basis of Gabija anti-phage defence and viral immune evasion
Bacteria encode hundreds of diverse defence systems that protect them from viral infection
and inhibit phage propagation,,,–. Gabija is one of the most prevalent anti-phage defence …
and inhibit phage propagation,,,–. Gabija is one of the most prevalent anti-phage defence …
Plasmid targeting and destruction by the DdmDE bacterial defence system
Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation
through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on …
through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on …
Molecular basis of RADAR anti-phage supramolecular assemblies
Y Gao, X Luo, P Li, Z Li, F Ye, S Liu, P Gao - Cell, 2023 - cell.com
Adenosine-to-inosine RNA editing has been proposed to be involved in a bacterial anti-
phage defense system called RADAR. RADAR contains an adenosine triphosphatase …
phage defense system called RADAR. RADAR contains an adenosine triphosphatase …
The structural basis of hyperpromiscuity in a core combinatorial network of type II toxin–antitoxin and related phage defense systems
Toxin-antitoxin (TA) systems are a large group of small genetic modules found in
prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two …
prokaryotes and their mobile genetic elements. Type II TAs are encoded as bicistronic (two …
Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements
The co-evolution of prokaryotes, phages and mobile genetic elements (MGEs) has driven
the diversification of defense and anti-defense systems alike. Anti-defense proteins have …
the diversification of defense and anti-defense systems alike. Anti-defense proteins have …
[HTML][HTML] A comprehensive resource for exploring antiphage defense: DefenseFinder webservice, Wiki and databases
In recent years, a vast number of novel antiphage defense mechanisms were uncovered. To
facilitate the exploration of mechanistic, ecological, and evolutionary aspects related to …
facilitate the exploration of mechanistic, ecological, and evolutionary aspects related to …
[HTML][HTML] Principles of bacterial innate immunity against viruses
All organisms must defend themselves against viral predators. This includes bacteria, which
harbor immunity factors such as restriction-modification systems and CRISPR-Cas systems …
harbor immunity factors such as restriction-modification systems and CRISPR-Cas systems …
Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense
SIR2-HerA, a bacterial two-protein anti-phage defense system, induces bacterial death by
depleting NAD+ upon phage infection. Biochemical reconstitution of SIR2, HerA, and the …
depleting NAD+ upon phage infection. Biochemical reconstitution of SIR2, HerA, and the …