Type IV secretion systems: advances in structure, function, and activation
Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …
From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective
G Waksman - EMBO reports, 2019 - embopress.org
Conjugation is the process by which bacteria exchange genetic materials in a unidirectional
manner from a donor cell to a recipient cell. The discovery of conjugation signalled the dawn …
manner from a donor cell to a recipient cell. The discovery of conjugation signalled the dawn …
Cryo-EM structure of a type IV secretion system
Bacterial conjugation is the fundamental process of unidirectional transfer of DNAs, often
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …
plasmid DNAs, from a donor cell to a recipient cell. It is the primary means by which …
Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids
X Liu, P Khara, ML Baker, PJ Christie, B Hu - Nature communications, 2022 - nature.com
Bacterial type IV secretion systems (T4SSs) are largely responsible for the proliferation of
multi-drug resistance. We solved the structure of the outer-membrane core complex …
multi-drug resistance. We solved the structure of the outer-membrane core complex …
The rich tapestry of bacterial protein translocation systems
PJ Christie - The protein journal, 2019 - Springer
The translocation of proteins across membranes is a fundamental cellular function. Bacteria
have evolved a striking array of pathways for delivering proteins into or across cytoplasmic …
have evolved a striking array of pathways for delivering proteins into or across cytoplasmic …
In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
Helicobacter pylori colonizes about half of humans worldwide, and its presence in the
gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric …
gastric mucosa is associated with an increased risk of gastric adenocarcinoma, gastric …
Biological and structural diversity of type IV secretion systems
YG Li, B Hu, PJ Christie - Microbiology spectrum, 2019 - Am Soc Microbiol
The bacterial type IV secretion systems (T4SSs) are a functionally diverse superfamily of
secretion systems found in many species of bacteria. Collectively, the T4SSs translocate …
secretion systems found in many species of bacteria. Collectively, the T4SSs translocate …
In Situ Visualization of the pKM101-Encoded Type IV Secretion System Reveals a Highly Symmetric ATPase Energy Center
P Khara, L Song, PJ Christie, B Hu - MBio, 2021 - Am Soc Microbiol
Bacterial conjugation systems are members of the type IV secretion system (T4SS)
superfamily. T4SSs can be classified as “minimized” or “expanded” based on whether they …
superfamily. T4SSs can be classified as “minimized” or “expanded” based on whether they …
Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines
Bacterial type IV secretion systems (T4SSs) are a versatile family of macromolecular
translocators, collectively able to recruit diverse DNA and protein substrates and deliver …
translocators, collectively able to recruit diverse DNA and protein substrates and deliver …
Cryo-EM structure of a conjugative type IV secretion system suggests a molecular switch regulating pilus biogenesis
Conjugative type IV secretion systems (T4SS) mediate bacterial conjugation, a process that
enables the unidirectional exchange of genetic materials between a donor and a recipient …
enables the unidirectional exchange of genetic materials between a donor and a recipient …