The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane
targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) …

The three-dimensional structure of the human immunodeficiency virus–type 1 (HIV-1)
nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of the genomic …

The 5′-leader of the HIV-1 genome regulates multiple functions during viral replication via
mechanisms that have yet to be established. We developed a nuclear magnetic resonance …

The diploid genome of all retroviruses is made of two homologous copies of RNA intimately
associated near their 5'end, in a region called the dimer linkage structure. Dimerization of …

The incorporation of viral genomes into particles has never previously been imaged in live
infected cells. Thus, for many viruses it is unknown how the recruitment and packaging of …

The RNA genome of the human immunodeficiency virus type-1 (HIV-1) contains a∼ 120
nucleotide Ψ-packaging signal that is recognized by the nucleocapsid (NC) domain of the …

The selective encapsidation of retroviral RNA requires sequences in the Gag protein, as well
as a cis-acting RNA packaging signal (psi site) near the 5'end of the genomic transcript. Gag …

RNA-RNA interactions govern a number of biological processes. Several RNAs, including
natural sense and antisense RNAs, interact by means of a two-step mechanism: recognition …