Reactive oxygen species (ROS) act as a double-edged sword in cancer, where low levels of
ROS are beneficial but excessive accumulation leads to cancer progression. Elevated levels …

Survivin is a component of the chromosomal passenger complex, which includes Aurora B,
INCENP, and Borealin, and is required for chromosome segregation and cytokinesis. We …

The human pathogen Helicobacter pylori represents a risk factor for the development of
gastric diseases including cancer. The H. pylori-induced transcription factor nuclear factor …

Ubiquitin-specific protease 13 (USP13) is one of the most important deubiquitinases
involved in various diseases. As deubiquitinases are components of the deubiquitination …

Background Gastric cancer is a highly prevalent cancer type and the underlying molecular
mechanisms are not fully understood. Ubiquitin-specific peptidase (USP) 29 has been …

Background Ubiquitin‐mediated degradation of the Mas‐related G protein‐coupled receptor
C (MrgC) reduces the number of receptors. However, the specific deubiquitinating enzyme …

Proteins related to the ubiquitin-proteasome system play an important role during the
differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in …

Antarctica is the most extreme continent of Earth, with strong winds, freezing temperatures
on land, and ocean temperatures constantly below 0° C. Nonetheless, the Antarctic Ocean is …

Dysfunction or dysregulation of deubiquitination is closely related to the initiation and
development of multiple cancers. Targeted regulation of deubiquitination has been …

Abstract Here, a series of 3-(6-aminopyridin-3-yl) benzamide derivatives were designed and
synthesized. Cell viability assay indicated that most compounds exhibited potent …