Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Aging and cancer exhibit apparent links that we will examine in this review. The null
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …

Aging clocks have provided one of the most important recent breakthroughs in the biology of
aging, and may provide indicators for the effectiveness of interventions in the aging process …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …

Epigenetic inheritance is another piece of the puzzle of nongenetic inheritance, although the
prevalence, sources, persistence, and phenotypic consequences of heritable epigenetic …

Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Over the past decade, epigenetic clocks have emerged as powerful machine learning tools,
not only to estimate chronological and biological age but also to assess the efficacy of anti …

Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …