The most life-threatening aspects of the oncogenic process are invasion and metastasis.
Even though the clinical significance of such expression of the malignant phenotype has …

A group of coordinated cellular processes, not just one gene product, is responsible for
invasion and metastasis, the most life-threatening aspect of cancer. It is now recognized that …

This paper describes several salivary components and their distribution in other mucosal
secretions. Histatins are polypeptides which possess exceptional anti-fungal and anti …

The process of cancer metastasis is sequential and selective and contains stochastic
elements. The growth of metastases represents the endpoint of many lethal events that few …

▪ Abstract A significant number of exciting papain-like cysteine protease structures have
been determined by crystallographic methods over the last several years. This trove of data …

Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which
collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors …

The successful penetration of endothelial basement membranes is an important process in
the formation of hematogenous tumor metastases. Heparan sulfate (HS) proteoglycan is a …

The major characteristic of malignant tumor cells is their ability to invade foreign tissues and
form metastatic foci at distant locations in the body. At the early stage of invasion the tumor …

Cancer cells are genetically predisposed to contribute to the formation of a malignant tumor.
As a population they do not respect tissue boundaries, but penetrate into the surrounding …

Biochemical and genetic analysis of apoptosis has determined that intracellular proteases
are key effectors of cell death pathways. In particular, early studies have pointed to the …