The role of microglia in retinal neurodegeneration: Alzheimer's disease, Parkinson, and glaucoma
Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …
The molecular basis of retinal ganglion cell death in glaucoma
M Almasieh, AM Wilson, B Morquette… - Progress in retinal and …, 2012 - Elsevier
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …
results in visual field loss and irreversible blindness. A crucial element in the …
Glaucoma: the retina and beyond
BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
Here, we use a mouse model (DBA/2J) to readdress the location of insult (s) to retinal
ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an …
ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an …
Glaucoma as a neurodegenerative disease
Glaucoma as a neurodegenerative disease is a valid working hypothesis to understand
neural injury in the visual system. This paradigm may stimulate the discovery of innovative …
neural injury in the visual system. This paradigm may stimulate the discovery of innovative …
What is the present pathogenetic concept of glaucomatous optic neuropathy?
J Flammer, M Mozaffarieh - Survey of ophthalmology, 2007 - Elsevier
Glaucomatous optic neuropathy implies loss of neural tissue, activation of glial cells, tissue
remodeling, and change of blood flow. The blood flow reduction is not only secondary but …
remodeling, and change of blood flow. The blood flow reduction is not only secondary but …
[HTML][HTML] Spectral domain optical coherence tomography for glaucoma (an AOS thesis)
JS Schuman - Transactions of the American Ophthalmological …, 2008 - ncbi.nlm.nih.gov
Purpose Optical coherence tomography (OCT) is a rapidly evolving, robust technology that
has profoundly changed the practice of ophthalmology. Spectral domain OCT (SD-OCT) …
has profoundly changed the practice of ophthalmology. Spectral domain OCT (SD-OCT) …
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging
Purpose.: Weexamined changes of the central nervous system in patients with advanced
primary open-angle glaucoma (POAG). Methods.: The clinical observational study included …
primary open-angle glaucoma (POAG). Methods.: The clinical observational study included …
Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies
NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …
Glaucoma and the brain: trans-synaptic degeneration, structural change, and implications for neuroprotection
A recent hypothesis to enter the literature suggests that glaucoma is a neurodegenerative
disease. The basis for this has been the finding of central nervous system changes in …
disease. The basis for this has been the finding of central nervous system changes in …