Cell-penetrating peptides for transmucosal delivery of proteins

J Wu, S Roesger, N Jones, CMJ Hu, SD Li - Journal of Controlled Release, 2024 - Elsevier
Enabling non-invasive delivery of proteins across the mucosal barriers promises improved
patient compliance and therapeutic efficacies. Cell-penetrating peptides (CPPs) are …

Polymersomes for therapeutic protein and peptide delivery: towards better loading properties

C Hua, L Qiu - International Journal of Nanomedicine, 2024 - Taylor & Francis
Therapeutics based on proteins and peptides have profoundly transformed the landscape of
treatment for diseases, from diabetes mellitus to cancers, yet the short half-life and low …

[HTML][HTML] 3D printed CoCrMo personalised load-bearing meta-scaffold for critical size tibial reconstruction

CT Wanniarachchi, A Arjunan, A Baroutaji… - Annals of 3D Printed …, 2024 - Elsevier
Porous scaffolds have evolved, allowing personalised 3D-printed structures that can
improve tissue reconstruction. By using scaffolds with specific porosity, Poisson's ratio and …

Fast disintegrating dosage forms of mucoadhesive-based nanoparticles for oral insulin delivery: Optimization to in vivo evaluation

B Chamsai, P Opanasopit, W Samprasit - International Journal of …, 2023 - Elsevier
The aim of this work was to develop fast disintegrating dosage forms, including fast
disintegrating tablets (FDTs) and films (FDFs), for oral insulin delivery incorporating …

Exploitation of transdermal nanobilosomal gel platforms for ameliorating anti-diabetic activity of empagliflozin following I-optimal design

TM Ibrahim - Journal of drug delivery science and technology, 2023 - Elsevier
The current study aimed to optimize a bilosomal gel (bilo-gel) formulation loaded with anti-
diabetic empagliflozin. Enhancement of transdermal delivery of empagliflozin was targeted …

Nanotechnology-based mucoadhesive and mucus-penetrating drug-delivery systems for transbuccal drug delivery

DD Desai, J Manikkath, H Lad, M Kulkarni… - …, 2023 - Taylor & Francis
Buccal drug-delivery systems present a promising approach for the drug delivery to the
buccal mucosa, addressing oral cavity-specific problems, enabling systemic delivery and …

[HTML][HTML] Use of Silybum marianum Extract and Bio-Ferment for Biodegradable Cosmetic Formulations to Enhance Antioxidant Potential and Effect of the Type of …

E Kucharska, R Sarpong, A Bobkowska, J Ryglewicz… - Applied Sciences, 2023 - mdpi.com
In the present study, extract (E) and bio-ferment (B) were obtained from ground and defatted
thistle seeds of Silybum marianum. Their antioxidant activity was assessed using the DPPH …

Modified release, enriched biocompatibility, and enhanced oral bioavailability as precious features of nitrofurantoin-loaded polymeric nanoparticles

MA Tantawy, HM Elsabbagh, NM Saleh - Journal of Drug Delivery Science …, 2024 - Elsevier
Nitrofurantoin (NTF) is a first-line therapy for treating urinary tract infections. However, gastric
upset, short half-life, and poor bioavailability of NTF are major challenges for clinical use …

Predicting long-term stability of an oral delivered antibody drug product with accelerated stability assessment program modeling

L Dai, J Davis, K Nagapudi, P Mantik… - Molecular …, 2023 - ACS Publications
The oral delivery of protein therapeutics offers numerous advantages for patients but also
presents significant challenges in terms of development. Currently, there is limited …