Antibiotic resistance has become an indispensably alarming menace to the global
community. The primary factors are overuse and abuse of antibiotics, lack of novel …

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly
common and are causing a global health crisis. Antibiotic resistance is encoded by several …

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …

Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

Antimicrobial resistance has been recognized as one of the most pressing public health and
societal issues of our times. The problem is most acute in gram-negative bacteria, where …

The resistance of microorganisms to antibiotics has been develo** for more than 2 billion
years and is widely distributed among various representatives of the microbiological world …

Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for
the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and …

The growing prevalence of carbapenem resistance in Enterobacteriaceae worldwide is a
major concern. New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance …

(Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter
baumannii, Pseudomonas aeruginosa, and Enterobacter spp) pathogens, has become a …

We measured in vitro activity of plazomicin, a next-generation aminoglycoside, and other
aminoglycosides against 50 carbapenem-resistant Klebsiella pneumoniae strains from two …