The prevalence of iron overload cardiomyopathy (IOC) is increasing. The spectrum of
symptoms of IOC is varied. Early in the disease process, patients may be asymptomatic …

BACKGROUND: The prevalence of primary (hereditary) hemochromatosis and secondary
iron overload (hemosiderosis) is reaching epidemic levels worldwide. Iron-overload leads to …

This aim of this statement is to report an expert consensus on the diagnosis and treatment of
cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover …

Objectives: The goal of this study was to characterize left ventricular diastolic function in the
sickle cell disease (SCD) population and to relate echocardiographic measures of …

Myocardial ischemia-reperfusion (I/R) injury triggers several cell death types, including
apoptosis, autophagy, and ferroptosis. Licochalcone A (LCA), a natural flavonoid compound …

Regular monitoring of left ventricular ejection fraction (LVEF) for thalassemia major is widely
practiced, but its informativeness for iron chelation treatment is unclear. Eighty-one patients …

Tissue Doppler imaging (TDI) is a new echocardiographic technique employing the Doppler
principle to measure the velocity of myocardial segments and other cardiac structures. It is …

The thalassemias are common monogenic disorders of hemoglobin synthesis. β-
thalassemias are the most important among the thalassemia syndromes and have become a …

Magnetic resonance imaging (MRI) appears to be useful for monitoring iron overload in
thalassaemia. We studied 106 patients with beta‐thalassaemia: 80 with thalassaemia major …

Patients with thalassemia major have inevitably suffered from complications of the disease,
due to iron overload. Among such complications, cardiomyopathy is the leading cause of …