Living cells can sense mechanical forces and convert them into biological responses.
Similarly, biological and biochemical signals are known to influence the abilities of cells to …

Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in
order to activate transcription in response to growth signals or environmental cues …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

DNA as the genetic material is a topic of intense interest in the 21st century, with the
genomes of many organisms having been sequenced. The double helix structure …

A fundamental principle of exponential bacterial growth is that no more ribosomes are
produced than are necessary to support the balance between nutrient availability and …

Genome architecture has proven to be critical in determining gene regulation across almost
all domains of life. While many of the key components and mechanisms of eukaryotic …

We determined the genome-wide distribution of the nucleoid-associated protein Fis in
Escherichia coli using chromatin immunoprecipitation coupled with high-resolution whole …

Regulation of cellular growth implies spatiotemporally coordinated programmes of gene
transcription. A central question, therefore, is how global transcription is coordinated in the …

The multistep kinetics through which DNA-binding proteins bind their targets are heavily
studied, but relatively little attention has been paid to proteins leaving the double helix …

In Escherichia coli, the transcriptional activity of many promoters is strongly dependent on
the negative superhelical density of chromosomal DNA. This, in turn, varies with the growth …